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Citation of academic research papers is a very important result for academic researchers, and their utilization is becoming an important evaluation factor. Most papers are composed of authors' keywords. However, there may be some papers with little relevance between the textual content and the presented keywords. Therefore, it is necessary to extract and present important keywords through objective methods for titles and abstracts of theses. In this paper, we present the development results of important keywords through data visualization for academic research papers.

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Large-scale resolution of epoxides by the yeast Rhodotorula glutinis was demonstrated in an aqueous/organic two-phase cascade membrane bioreactor. Due to the chemical instability and low solubility of epoxides in aqueous phases, an organic solvent was introduced into the reaction mixture in order to enhance resolution of epoxide. A cascade hollow-fiber membrane bioreactor was used (i) to minimize the toxicity of organic solvents towards the epoxide hydrolase of Rhodotorula glutinis, and (ii) to remove inhibitory amounts of formed diol from the yeast cell containing aqueous phase. Dodecane was selected as a suitable solvent and 1,2-epoxyhexane as a model substrate. By use of this membrane bioreactor, highly concentrated (0.9 M in dodecane) enantiopure (>98% ee) (S)-1,2-epoxyhexane (6.5 g, 30% yield) was obtained from its racemic mixture.

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