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À°¹ÌÁöȲÅÁ°¡¹Ì¹æÀÌ PQ(paraquat)·Î À¯¹ßµÈÇãÆÄ ¼Õ»ó ³í¹® ÀÚ·áÀÔ´Ï´Ù
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Á¦¸ñ : À°¹ÌÁöȲÅÁ°¡¹Ì¹æ(ë»Ú«ò¢üÜ÷·Ê¥Ú«Û°)ÀÌ PQ (paraquat)·Î À¯¹ßµÈ ÇãÆÄ ¼Õ»ó¿¡ ¹ÌÄ¡´Â ¿µÇâ
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¹ßÇàÇÐȸ : Çѱ¹º¸°Ç±âÃÊÀÇÇÐȸ [The Korean Health & Fundamental Medical Science Society]
¹ßÇàÁ¤º¸ : Á¦ 1±Ç 1È£ pp.17-22(6 pages)
¹ßÇà³âµµ : 2008
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Based on the literature review
, this study was attempted to see the beneficial effects of oriental medicine onthe aging process by using the senescence accelerated mouse (SAM). Paraquat (PQ, 2¡¿10-7 mg/kg) was administered tothe four-month old senescence accelerated mouse to induce the oxidative and cellular damage. The experimental groupsare administered with YukmiGa followed by PQ treatment. The lung samples were obtained after sacrificing them for electronmicroscopical observation. In the lung, PQ caused a hugh damage on pneumocyte type I and type II cells from cellulartoxicity. In the YukmiGa treatment groups, slightly damaged cellular organelles were observed from 1 day to 6-day treatmentgroups. These experimental groups showed normal endothelial cells of capillary and alveolar endothelial cells. It isassumed that YulmiGa could suppress the cellular toxicity from PQ treatment in the lung. Also, YulmiGa seems good effectfor its anti-aging action at in the SAM model. (ÀÌÇÏ »ý·«)
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