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1Àå INTRODUCTION
2Àå METHODS
3Àå RESULTS
4Àå DISCUSSION
dietary magnesium intake and risk of stroke: a meta-analysis of prospective studiesxxx-xxx
susanna c larsson, nicola orsini, and alicja wolk
am j clin nutr xxxx. xx
xxxxx-xxx. introduction magnesium
inversely associated with risk factors for stroke such as hypertension, metabolic syndrome, type 2 diabetes
reduces diastolic blood pressure, fasting c-peptide and insulin concentrations
animal studies
favorable effects on plasma glucose and blood lipid
magnesium deficiency : susceptibility of lipoproteins to peroxidation¡è
potentially reduce risk of stroke.
objective
relation between dietary magnesium intake and risk of stroke summarized
systematic review and dose-response meta-analysis to assess
methods literature search and selection pubmed and embase from january 1966 through september 2011
key words ¡°magnesium intake¡± combined with ¡°stroke.¡±
reviewed reference lists of retrieved articles to identify additional relevant studies.
no language restrictions inclusion criteria:
1) prospective design
2) the exposure of interest was magnesium intake
3) the outcome was stroke,
4) the studies reported rrs with 95% cis for 3 quantitative categories of magnesium intake.
rrs had to at least be adjusted for age and sex
methods data extraction
extracted from each study: first author¡¯s last name, publication year, name of the cohort study, study location, years of follow-up, sex, age, sample size (number of cases and total number of participants), magnesium intake categories, covariates adjusted for in the multivariable analysis, and rrs with their 95% cis for each category of magnesium intake.
conducted independently by 2 investigators (scl and no) with disagreements resolved by consensus.
methods statistical analysis
2-stage, random-effects, dose-response meta-analysis
restricted cubic splines (ÀÌÇÏ »ý·«)
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